About antifungal and antiparasitic drugs

About antifungal and antiparasitic drugs

هذا الاختبار مكون من 40 سؤالًا يغطي موضوعات متعددة من محاضرات حول الأدوية المضادة للفطريات والطفيليات، ويهدف إلى تقييم فهم الطالب لآلية عمل الأدوية، خصائصها الدوائية، والآثار الجانبية المحتملة. تنوعت الأسئلة بين "صح أو خطأ"، "اختيار من متعدد"، و"أكمل الفراغ"، مما يسمح بقياس مستوى التحصيل العلمي بشكل شامل. الأسئلة صُممت باللغة الإنجليزية لتناسب السياق الأكاديمي الطبي العالمي، والإجابات النموذجية مدرجة في نهاية الاختبار لتسهيل المراجعة الذاتية.

والآن إليك نص الاختبار باللغة الإنجليزية:

Antifungal and Antiparasitic Drugs Quiz (40 Questions)

I. True or False (15 Questions)

1. Amphotericin B binds more strongly to bacterial membranes than fungal membranes. (False)

2. Amphotericin can form pores in fungal cell membranes. (True)

3. Nystatin is well absorbed from the gastrointestinal tract. (False)

4. Griseofulvin is a broad-spectrum antifungal agent. (False)

5. Fluconazole inhibits the synthesis of ergosterol in fungal membranes. (True)

6. Ketoconazole can cause hepatotoxicity. (True)

7. Flucytosine is safe to use alone in all systemic fungal infections. (False)

8. Terbinafine inhibits squalene epoxidase enzyme. (True)

9. Amphotericin B is commonly given orally for systemic infections. (False)

10. Miltefosine was originally developed as an antifungal drug. (False)

11. Sodium stibogluconate is used to treat leishmaniasis. (True)

12. Metronidazole acts on the cyst form of Entamoeba histolytica. (False)

13. Quinine can cause cinchonism at high plasma levels. (True)

14. Mefloquine is effective against the hepatic forms of Plasmodium vivax. (False)

15. Halofantrine may cause QT prolongation and cardiac arrhythmias. (True)

II. Multiple Choice (15 Questions)
16. Which drug forms pores in fungal membranes?
A. Griseofulvin
B. Amphotericin B
C. Fluconazole
D. Miconazole
(Answer: B)

17. What is the mechanism of action of fluconazole?
    A. Inhibits fungal mitosis
    B. Disrupts microtubules
    C. Inhibits ergosterol synthesis
    D. Acts as ionophore
    (Answer: C)

18. Which of the following is mainly used for Candida infections of the skin and mucosa?
    A. Amphotericin B
    B. Flucytosine
    C. Nystatin
    D. Ketoconazole
    (Answer: C)

19. Which drug is associated with gynecomastia in males?
    A. Itraconazole
    B. Ketoconazole
    C. Fluconazole
    D. Amphotericin B
    (Answer: B)

20. Which antifungal is a known potent enzyme inducer?
    A. Griseofulvin
    B. Amphotericin
    C. Nystatin
    D. Miconazole
    (Answer: A)

21. Which drug is highly lipophilic and used for nail infections?
    A. Amphotericin
    B. Terbinafine
    C. Nystatin
    D. Flucytosine
    (Answer: B)

22. Which one is a common unwanted effect of amphotericin B?
    A. Hepatitis
    B. Retinopathy
    C. Renal toxicity
    D. CNS depression
    (Answer: C)

23. Which of the following is used for asymptomatic amoebiasis?
    A. Metronidazole
    B. Quinine
    C. Diloxanide furoate
    D. Miltefosine
    (Answer: C)

24. What causes malaria?
    A. Bacteria
    B. Protozoa
    C. Fungi
    D. Viruses
    (Answer: B)

25. What is the mechanism of chloroquine?
    A. Enhances DNA synthesis
    B. Blocks mitosis
    C. Inhibits haem polymerase
    D. Forms ion channels
    (Answer: C)

26. What is the route of administration of sodium stibogluconate?
    A. Oral
    B. Inhalation
    C. Intramuscular/Intravenous
    D. Topical
    (Answer: C)

27. Which of the following is NOT an azole derivative?
    A. Ketoconazole
    B. Fluconazole
    C. Terbinafine
    D. Miconazole
    (Answer: C)

28. Which drug is NOT safe in pregnancy?
    A. Chloroquine
    B. Mefloquine
    C. Nystatin
    D. Griseofulvin
    (Answer: D)

29. The most dangerous Plasmodium species is:
    A. P. vivax
    B. P. ovale
    C. P. malariae
    D. P. falciparum
    (Answer: D)

30. Which of the following can cause cinchonism?
    A. Terbinafine
    B. Quinine
    C. Amphotericin
    D. Ketoconazole
    (Answer: B)

III. Fill in the Blank (10 Questions)
31. The main site of action of amphotericin B is the ________.
(Answer: fungal cell membrane)

32. Fluconazole reaches high concentrations in the ________ fluid.
    (Answer: cerebrospinal)

33. Griseofulvin interacts with ________ to inhibit fungal mitosis.
    (Answer: microtubules)

34. The antifungal drug ________ is usually given with amphotericin B for synergistic effect.
    (Answer: flucytosine)

35. ________ is the drug of choice for invasive amoebiasis.
    (Answer: Metronidazole)

36. Terbinafine inhibits ________ epoxidase.
    (Answer: squalene)

37. Mefloquine has a very long ________ (up to 30 days).
    (Answer: half-life)

38. Chloroquine is effective against the ________ forms of Plasmodium.
    (Answer: erythrocytic)

39. The side effect of ringing in the ears with quinine is called ________.
    (Answer: tinnitus)

40. Miltefosine induces ________ in parasites.
    (Answer: apoptosis)

Answer 

True or False:

1. False

2. True

3. False

4. False

5. True

6. True

7. False

8. True

9. False

10. False

11. True

12. False

13. True

14. False

15. True

Multiple Choice: 16. B
17. C
18. C
19. B
20. A
21. B
22. C
23. C
24. B
25. C
26. C
27. C
28. D
29. D
30. B

Fill in the Blank: 31. fungal cell membrane
32. cerebrospinal
33. microtubules
34. flucytosine
35. Metronidazole
36. squalene
37. half-life
38. erythrocytic
39. tinnitus
40. apoptosis